Studies on the neutralizing antibody to herpes simplex virus
- 31 May 1981
- journal article
- research article
- Published by Springer Nature in Archiv für die gesamte Virusforschung
- Vol. 69 (2), 105-115
- https://doi.org/10.1007/bf01315154
Abstract
A quantitative analysis was carried out on type specific antibody developed in rabbits primed with three doses of one type of herpes simplex virus at two week intervals, followed by administration of another type of virus. Complement-requiring neutralizing antibody assay and mutual absorbing methods were used. The homotype specific antibody produced against the type of virus used for priming persisted at a constant level for a long period, despite the lack of antigenic stimuli by the same type after priming. The homotype specific antibody was not affected by the heterotypic antigenic stimuli. On the other hand, the heterotype specific antibody developed after the first or second injection of heterotypic virus, and the titer tended to decline, reaching undetectable levels at 9 months. However, the heterotype specific antibody was produced rapidly after the third injection of virus at 9 months and the titers exceeded or closed to those of the homotype specific antibody. The homotype specific antibodies were mainly distributed in the IgG fraction, while the IgM fraction contained mainly the heterotype specific antibodies. In the relationship between type specific antibody response and the values of II/I index, the coexistence of both type specific antibodies was apparent in sera with the values of 91 to 117 of II/I index and in the IgG fraction with the values of 90 to 115, respectively.Keywords
This publication has 33 references indexed in Scilit:
- Studies on the neutralizing antibody to herpes simplex virusArchiv für die gesamte Virusforschung, 1981
- Relationship between antigenic type of virus and antibody response in female patients with herpes genitalisJournal of Medical Virology, 1980
- Studies on the Neutralization of Herpes Simplex VirusMicrobiology and Immunology, 1978
- CLINICAL AND VIROLOGICAL STUDIES ON GENITAL HERPESThe Lancet, 1976
- Type Specific and Type Common Antigens in Cells Infected with Herpes Simplex Virus Type 1 and on the Surfaces of Naked and Enveloped Particles of the VirusJournal of General Virology, 1974
- The Role of Type Specific and Cross Reacting Structural Antigens in the Neutralization of Herpes Simplex Virus Types 1 and 2Journal of General Virology, 1973
- Differentiation between Type 1 and Type 2 Strains of Herpes Simplex Virus by an Indirect Immunofluorescent TechniqueJournal of General Virology, 1971
- Genital herpes in two social groupsAmerican Journal of Obstetrics and Gynecology, 1971
- Typing of Herpesvirus hominis Strains by a Direct Immunofluorescent TechniqueExperimental Biology and Medicine, 1969
- The appearance of complement-requiring neutralizing antibodies by immunization and infection with herpes simplex virusVirology, 1964