Alpha-chain locus of the T-cell antigen receptor is involved in the t(10;14) chromosome translocation of T-cell acute lymphocytic leukemia.
Open Access
- 1 July 1987
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 84 (13), 4543-4546
- https://doi.org/10.1073/pnas.84.13.4543
Abstract
Human leukemic T cells carrying a t(10;14)(q24;q11) chromosome translocation were fused with mouse leukemic T cells, and the hybrids were examined for genetic markers of human chromosomes 10 and 14. Hybrids containing the human 10q+ chromosome had the human genes for terminal deoxynucleotidyltransferase that has been mapped at 10q23-q25 and for C.alpha. [the constant region of TCRA (the .alpha.-chain locus of the T-cell antigen receptor gene)], but not for V.alpha. (the variable region of TCRA). Hybrids containing the human 14q- chromosome retained the V.alpha. genes. Thus the 1411 breakpoint in the t(10;14) chromosome translocation directly involves TCRA, splitting the locus in a region between the V.alpha. and the C.alpha. genes. These results suggest that the translocation of the C.alpha. locus to a putative cellular protooncogene located proximal to the breakpoint at 10q24, for which we propose the name TCL3, results in its deregulation, leading to T-cell leukemia. Since hybrids with the 10q+ chromosome also retained the human terminal deoxynucleotidyltransferase gene, it is further concluded that the terminal deoxynucleotidyltransferase locus is proximal to the TLC3 gene, at band 10q23-q24.This publication has 16 references indexed in Scilit:
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