Dialysis arthropathy: amyloid or iron?
- 29 November 1986
- Vol. 293 (6559), 1392-1394
- https://doi.org/10.1136/bmj.293.6559.1392
Abstract
The clinical, biochemical, radiological, and pathological features in five cases of dialysis arthropathy were analysed. All patients were receiving long term haemodialysis and had had multiple blood transfusions. The arthropathy affected both large and small joints, was predominantly bilateral, and in all cases was associated with the carpal tunnel syndrome. In some instances joint pain was exacerbated during dialysis. In four cases the serum ferritin concentration was raised. Radiological examination showed a few juxta-articular cysts and erosions but most affected joints looked normal. All synovial tissue examined showed amyloid, which stained immunohistochemically for beta 2 microglobulin. Large amounts of iron were present in synovial tissue from affected joints. It is suggested that the deposits of iron, rather than amyloid, in synovial tissue may be the cause of the arthropathy. Iron may be derived locally as a result of haemarthrosis or it may be a manifestation of systemic iron overload.This publication has 14 references indexed in Scilit:
- Amyloid arthropathy in patients undergoing periodical haemodialysis for chronic renal failure: a new complication.Annals Of The Rheumatic Diseases, 1985
- Clinicopathological importance of deposits of amyloid in the femoral head.Journal of Clinical Pathology, 1985
- Amyloid deposits in human knee and hip jointsRheumatology International, 1985
- Chronic arthropathy in long-term hemodialysisAmerican Journal Of Medicine, 1985
- Erosive azotemic osteoarthropathyArthritis & Rheumatism, 1984
- Acute joint syndrome (AJS) and maintenance hemodialysis (HD).1979
- Serum β2-Microglobulin in Hemodialyzed PatientsNephron, 1978
- Ultrastructural characteristics of the synovial membrane in idiopathic haemochromatosis.Annals Of The Rheumatic Diseases, 1972
- Synovial biopsy in haemochromatosis arthropathy. Histological findings and iron deposition in relation to total body iron overload.Annals Of The Rheumatic Diseases, 1972
- 11 Hemophilic ArthropathyPublished by Wolters Kluwer Health ,1967