Suppression of in Vitro Lymphocyte Responses by Chloroquine

Abstract

THE antimalarial drug chloroquine has found clinical use in the suppression of some symptoms in rheumatoid arthritis and disseminated lupus erythematosus, diseases associated with abnormalities of the immune response.¹ Chloroquine has more recently been suggested as effective symptomatic therapy in infectious mononucleosis, a disease associated with abnormalities of lymphocytes and abnormal antibodies.² The current experiments were undertaken to study its effect on specific and nonspecific stimulation of cultured human peripheral blood lymphocytes to derive possible information Concerning its mechanism of action in the diseases mentioned above.Materials and MethodsPeripheral blood lymphocytes were obtained from normal subjects and cultured by . . .