Delayed Hypersensitivity to Herpes Simplex Virus in the Guinea Pig

Abstract

Guinea pigs experimentally infected with herpes simplex virus develop a hypersensitive skin reaction following the intradermal injection of the heat inactivated virus preparation. This response becomes detectable several hours after challenge, generally reaching a maximum intensity at 24 hr. The cutaneous response can be elicited within a week after sensitization. Sensitivity persists for at least 9 weeks. Cytologically, the central feature is an infiltration of mononuclear cells. The hypersensitivity can be transferred with cells but not with serum. It is concluded that the hypersensitive response to herpes simplex antigen is of the “delayed” type.