Impaired responsiveness of lymphocytes in patients with systemic lupus erythematosus.

  • 1 November 1974
    • journal article
    • Vol. 18 (3), 295-301
Abstract
Cellular immune responsiveness, as measured by lymphocyte transformation in one-way mixed leucocyte cultures (MLC) and in phytohaemagglutinin (PHA) stimulated cultures was evaluated in forty patients with systemic lupus erythematosus (SLE) and in seventy-four normal controls. The effect produced by sera from these subjects on in vitro lymphocyte reactivity was tested on autologous cells and on homologous responding cells from a constant panel of ten healthy volunteers.