REARRANGEMENT OF IMMUNOGLOBULIN HEAVY-CHAIN GENES IN T-CELL ACUTE LYMPHOBLASTIC-LEUKEMIA
- 1 January 1985
- journal article
- research article
- Vol. 65 (3), 725-729
Abstract
The arrangement of the Ig heavy chain genes by Southern blot analysis of DNA freshly obtained from marrow blast cells of 14 children with T cell acute lymphoblastic leukemia (T-ALL) using probes to the C.mu. and JH gene segments: At least one of the C.mu.-gene alleles was rearranged in 3 cases. In 2 of these, 1 C.mu.-gene had the germ-line configuration and 1 was rearranged, whereas both alleles were rearranged, whereas both alleles were rearranged in the third case. In 1 case, a rearranged heavy chain gene hybridized ot the C.mu.-region probe, but not to the JH probe, indicating that the entire JH region was deleted. Ig heavy chain gene rearrangements are not restricted to B lineage lymphoproliferative diseases in humans.This publication has 9 references indexed in Scilit:
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