Facile Quantification of Enantiomeric Excess and Concentration with Indicator-Displacement Assays: An Example in the Analyses of α-Hydroxyacids
- 1 March 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 126 (12), 3676-3677
- https://doi.org/10.1021/ja031839s
Abstract
An enantioselective indicator-displacement assay was developed to determine enantiomeric excess (ee) and concentration of α-hydroxyacid samples with two independent absorption measurements. The inherent relationship between the absorbance of the indicator-displacement ensemble and the overall concentration and ee of the analyte was established through solution equilibria.Keywords
This publication has 22 references indexed in Scilit:
- Controlling the Oxygenation Level of Hemoglobin by Using a Synthetic Receptor for 2,3-BisphosphoglycerateAngewandte Chemie International Edition, 2003
- The design of fluorescent sensors for anions: taking profit from the metal–ligand interaction and exploiting two distinct paradigmsDalton Transactions, 2003
- Determination of Inorganic Phosphate in Serum and Saliva Using a Synthetic ReceptorOrganic Letters, 2003
- Recent advances in the discovery of organometallic catalysts using high-throughput screening assaysCurrent Opinion in Chemical Biology, 2003
- Pyrophosphate Detection in Water by Fluorescence Competition Assays: Inducing Selectivity through the Choice of the IndicatorAngewandte Chemie International Edition, 2002
- High-Throughput Screening of Enantioselective Catalysts by ImmunoassayAngewandte Chemie International Edition, 2002
- Emerging methods for the rapid determination of enantiomeric excessChirality, 2002
- Synthesis and circular dichroism studies of N,N‐bis(2‐quinolylmethyl)amino acid Cu(II) complexes: Determination of absolute configuration and enantiomeric excess by the exciton coupling methodChirality, 2002
- Colorimetric chiral recognition by a molecular sensorNature, 1996
- A Reagent for Determining Optical Purities of Diols by Formation of Diastereomeric Arylboronate EstersAngewandte Chemie International Edition in English, 1994