DIFFERENTIAL BLOOD PRESSURE AND METABOLIC EFFECTS OF 9?-FLUOROCORTISOL IN MAN
- 1 June 1983
- journal article
- Published by Wiley in Clinical and Experimental Pharmacology and Physiology
- Vol. 10 (3), 351-354
- https://doi.org/10.1111/j.1440-1681.1983.tb00211.x
Abstract
The blood pressure and metabolic effects of 9 alpha-fluorocortisol at 0.15 mg/day and 1.5 mg/day were examined in man. At high dose, systolic pressure and body weight rose, and plasma [K+], urinary sodium excretion and renin concentration fell. At low dose similar metabolic effects were seen but blood pressure was unchanged. 9 alpha-Fluorocortisol has 'mineralocorticoid' effects in man at a dose which does not alter blood pressure. These studies do not provide evidence of a 'hypertensinogenic' class of steroid hormone action in man.Keywords
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