The article by Pross, et al.1 emphasizes the urgency of finding a suitable treatment for Reye's syndrome. This is underscored by the fact that most patients with this syndrome do not survive as noted in their article; that most conventional forms of therapy such as intravenous glucose, electrolyte and fluid replacement, and glucocorticoids do not seem to arrest the encephalopathy; and that as more physicians become acquainted with the syndrome the recognized incidence should increase.