Some Factors Influencing the Absorption of Griseofulvin from the Gastrointestinal Tract

Abstract

Some surface-active agents enhance the absorption of griseofulvin from suspensions administered to rats and man. The method of incorporating the agent into the suspension is important. No similar effect is observed with tablets of griseofulvin in man. The effect of particle size on the absorption of griseofulvin when administered as a suspension and as tablets has been studied in a statistically designed experiment in man. The results show that doses of 0.5 g. griseofulvin of surface area 0.35 m.2/g. or 0.25 g. of material with a surface area of 1.5 m.2/g. give similar concentrations of griseofulvin in the blood.