Oxygen Consumption and Cellular Ion Transport: Evidence for Adenosine Triphosphate to O 2 Ratio Near 6 in Intact Cell
- 6 June 1980
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 208 (4448), 1148-1150
- https://doi.org/10.1126/science.6246581
Abstract
Oxygen (O2) consumption and net K+ uptake were measured simultaneously upon reintroduction of K+ into a K+-depleted suspension of renal tubules. The K+/O2 stoichiometries of 11.8 +/- 0.2 and 8.4 +/- 0.6 were obtained for reduced nicotinamide adenine dinucleotide- and flavoprotein-linked substrates, respectively. These values complement classical K+ to adenosine triphosphate (ATP) and ATP/O2 stoichiometries, thereby demonstrating a remarkably efficient coupling between the processes of Na+- and K+-dependent adenosinetriphosphatase-mediated ion transport and oxidative phosphorylation within the intact cell.Keywords
This publication has 11 references indexed in Scilit:
- Coupling of active ion transport and aerobic respiratory rate in isolated renal tubules.Proceedings of the National Academy of Sciences, 1980
- The phosphorus/oxygen ratio of mitochondrial oxidative phosphorylationJournal of Biological Chemistry, 1979
- Active transport of sodium and potassium ions by the sodium and potassium ion-activated adenosine triphosphatase from renal medulla. Reconstitution of the purified enzyme into a well defined in vitro transport system.Journal of Biological Chemistry, 1977
- On the relationships between the stoichiometry of oxidative phosphorylation and the phosphorylation potential of rat liver mitochondria as functions of respiratory stateFEBS Letters, 1974
- The stoicheiometry of the sodium pumpThe Journal of Physiology, 1967
- The connexion between active cation transport and metabolism in erythrocytesBiochemical Journal, 1965
- The regulation of kidney respiration by sodium and potassium ionsBiochemical Journal, 1964
- Stoichiometry and Localization of Adenosine Triphosphate-dependent Sodium and Potassium Transport in the ErythrocyteJournal of Biological Chemistry, 1964
- Ion movements and oxygen consumption in kidney cortex slicesThe Journal of Physiology, 1963
- RESPIRATORY ENZYMES IN OXIDATIVE PHOSPHORYLATIONJournal of Biological Chemistry, 1955