Retinal Atrophy in Osteopetrosis
- 1 March 1968
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Ophthalmology (1950)
- Vol. 79 (3), 234-241
- https://doi.org/10.1001/archopht.1968.03850040236003
Abstract
A clinical and pathological description is given of a case of osteopetrosis with central retinal atrophy. In the outer retinal layers the rods and cones and their nuclei were very degenerate or absent, and in the inner retinal layers there was a marked gliosis with very few ganglion cells present. The optic nerves were also very gliosed; the nerve fibers showed a nodular type of degeneration and were very reduced in numbers. There was no narrowing of the optic foramina or bone pressure to have caused the optic nerve damage. From a review of the literature on osteopetrosis it seems that some of the cases of blindness attributed to optic atrophy could have been due to retinal degeneration. The pathological findings are similar to those produced by vitamin A deficiency in experimental animals.This publication has 4 references indexed in Scilit:
- Studies in OsteopetrosisArchives of Disease in Childhood, 1965
- Osteopetrosis*American Journal of Ophthalmology, 1964
- OsteopetrosisJournal of Bone and Joint Surgery, 1962
- The effect of vitamin A deficiency upon the retina of the ratJournal of Experimental Zoology, 1939