Hypercholesteremia in the Hereditary Obese-Hyperglycemic Syndrome of Mice

Abstract

Hypercholesteremia is an integral part of the hereditary obese-hyperglycemic syndrome. At 4-5 mos. serum cholesterol levels in the obese animals are double those characteristic of the nonobese littermates. Cholesterol levels are further increased in the obese animals by 2-wks. treatment with high protein and high carbohydrate diets, by fasting and growth hormone, and decreased by thyroxine. In the nonobese animals, ACTH and growth hormone increase, high carbohydrate and high protein diets and thyroxine lower cholesterol levels.