Localization of the Site of Action of Triamterene Diuretic.
- 1 June 1963
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 113 (2), 326-328
- https://doi.org/10.3181/00379727-113-28356
Abstract
Summary The pteridine compound triamterene was studied in 11 dogs using the stop flow method. These data support the hypothesis that the site of action of triamterene is the distal tubule of the kidney and that triamterene produces its natriuretic effect by reducing Na reabsorption in this area. No evidence was obtained for a proximal renal tubular effect.Keywords
This publication has 5 references indexed in Scilit:
- Triamterene, A New Natruretic AgentAnnals of Internal Medicine, 1962
- Stop Flow Analysis of Aldosterone and Steroidal Antagonist SC-8109 on Renal Tubular Sodium Transport Kinetics.Experimental Biology and Medicine, 1960
- Effects of Adrenalectomy and Aldosterone on Proximal and Distal Tubular Sodium Reabsorption.Experimental Biology and Medicine, 1958
- Graphical Placement of Transport Segments Along the Nephron From Urine Concentration Pattern Developed With Stop Flow TechniqueAmerican Journal of Physiology-Legacy Content, 1958
- Localization of Nephron Transport by Stop Flow AnalysisAmerican Journal of Physiology-Legacy Content, 1958