A multivalent lacto-N-fucopentaose III-lysyllysine conjugate decompacts preimplantation mouse embryos, while the free oligosaccharide is ineffective.
Open Access
- 1 November 1984
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 160 (5), 1591-1596
- https://doi.org/10.1084/jem.160.5.1591
Abstract
A multivalent lacto-N-fucopentaose (LNFP) III-lysyllysine conjugate was observed to decompact preimplantation mouse embryos. Decompaction was not obtained with free oligosaccharides (LNFP II and III), nor with multivalent LNFP II-lysyllysine or chitotriose-lysyllysine conjugates. These results suggest a role for X hapten recognition during compaction and suggest further that X hapten valency may play a key role in modulating this developmental process.Keywords
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