Involvement of d-amino acid oxidase in elimination of free d-amino acids in mice
- 1 January 1989
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 257 (1), 291-292
- https://doi.org/10.1042/bj2570291
Abstract
The physiological role of D-amino acid oxidase was investigated by using mutant ddY/DAO- mice lacking the enzyme. Free D-amino acid concentrations in the mutant mice were significantly higher than those of control ddY/DAO+ mice in kidney, liver, lung, heart, brain, erythrocytes, serum and urine. The results suggest that the enzyme is involved in the catabolism of free D-amino acids in the body, and that free D-amino acids are also excreted into urine.This publication has 13 references indexed in Scilit:
- d-Amino acid oxidase in mouse liverComparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1988
- Free d-amino acids in human plasma in relation to senescence and renal diseasesClinical Science, 1987
- Microdetermination of serum d-amino acidsAnalytical Biochemistry, 1985
- Involvement of D-Amino-Acid Oxidase in D-Amino Acid Utilization in the MouseJournal of Nutrition, 1984
- Brain and Kidney d-Amino Acid Oxidases Are Coded by a Single Gene in the MouseJournal of Neurochemistry, 1984
- Thiazolidine-2-carboxylic acid, an adduct of cysteamine and glyoxylate, as a substrate for D-amino acid oxidase.Journal of Biological Chemistry, 1982
- Reactions of cysteamine and other amine metabolites with glyoxylate and oxygen catalyzed by mammalian D-amino acid oxidase.Proceedings of the National Academy of Sciences, 1979
- D-valine as a selective agent for normal human and rodent epithelial cells in cultureCell, 1975
- ALANINE - CYCLOSERINE ANTAGONISM .6. DEMONSTRATION OF D-ALANINE IN SERUM OF GUINEA PIGS AND MICE1965
- Flavin enzymes in liver and kidney of rats from birth to weaningJournal of Cellular and Comparative Physiology, 1958