The distribution of tritium‐labelled prostaglandin E1 injected in amounts sufficient to produce central nervous effects in cats and chicks

Abstract

1 After injection of tritiated prostaglandin E₁ into the lateral cerebral ventricle, the carotid and vertebral arteries and the aorta in cats, only a small proportion of the radioactivity was recovered from the central nervous system. 2 Similar results were obtained when the prostaglandin was given intravenously and intra-arterially to chicks. 3 The results of this study confirm work in other species (Hansson & Samuelsson, 1965; Samuelsson, 1964, 1965) and suggest that prostaglandin E₁ exerts its central pharmacological actions in small concentrations.