Routine experience of the mouse-protection assay of pertussis vaccine
- 1 March 1957
- journal article
- Published by Cambridge University Press (CUP) in Epidemiology and Infection
- Vol. 55 (1), 45-49
- https://doi.org/10.1017/s0022172400061258
Abstract
The mouse-protection test is discussed as a routine procedure. It has been shown that the assay is exceptionally subject to variation and that an average slope of 1·47 has been found over a year. With this slope and tests involving 90–180 mice it is possible tobe reasonably sure that a vaccine actually 3 times as potent as needed passes a test which lays down that the lower fiducial limit (P = 0·95) should exceed the specified requirement. For a vaccine only 1·5 times as potent as needed, much more extensive laboratory work would be necessary.Keywords
This publication has 5 references indexed in Scilit:
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- Litter-Mate Assays of Pertussis VaccineEpidemiology and Infection, 1955
- Problems in the measurement of immunity and of the potency of immunizing agents.1954
- Mouse Protection Tests in the Study of Pertussis Vaccine: A Comparative Series Using the Intracerebral Route for Challenge.1947
- Mouse Protection Tests in the Study of Pertussis VaccineAmerican Journal of Public Health and the Nations Health, 1947