A MECHANISM FOR GENETIC RECOMBINATION GENERATING ONE PARENT AND ONE RECOMBINANT
- 1 October 1969
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 64 (2), 573-577
- https://doi.org/10.1073/pnas.64.2.573
Abstract
A mechanism is proposed for generating one parental and one recombinant genome in a single recombination event between two DNA molecules. Three stages of the event are described: initiation, replication, and return. Initiation requires breakage and joining of strands. Replication proceeds through a biparental "replication fork" generated in initiation. Return also involves breakage and joining of strands. Some of the implications of such a mechanism for genetic recombination are discussed.Keywords
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