EXPERIMENTAL TOXOCARA CANIS INFECTION IN CYNOMOLGUS MACAQUES (MACACA-FASCICULARIS)

Abstract

Visceral larva migrans was produced in 16 cynomolgus macaques (M. fascicularis) experimentally inoculated with 45,000 embryonated eggs of T. canis as a single bolus or in 3 divided doses. The hematologic and serologic changes were similar to those observed in children with visceral Toxocara infection. Neurologic signs developed in 3 animals and were characterized by ataxia and nystagmus. Growth rates were diminished in inoculated animals when compared with the rates in noninoculated controls. Diagnostic antibody titers as measured by enzyme-linked immunosorbent assay were noted in all inoculated macaques by the 4th week, and these titers persisted during the 7 mo. period of observation. Antibody to Toxocara was not detected in the aqueous or vitreous humors. Lesions comprised severe granulomatous hepatitis and encephalomyelitis. Intraocular lesions associated with larval migration were not observed.