Autoantibodies in Untreated and Treated Essential Hypertension. I
- 12 January 1978
- journal article
- research article
- Published by Wiley in Acta Medica Scandinavica
- Vol. 203 (1-6), 55-59
- https://doi.org/10.1111/j.0954-6820.1978.tb14831.x
Abstract
Using the indirect immunofluorescence method, autoantibodies (AB) of Ig[immunoglobulin]G and IgM classes were investigated in sera from 161 consecutive patients with essential hypertension and compared with those from 78 healthy normotensive subjects of the same composition by age and sex, and without any family history of hypertension. The frequency of 1 or more AB was as high in 78 untreated (15.3%) as in 83 treated patients (13.0%) and was 9.0% in the controls. In the treated patients, the AB were associated with heart involvement (P < 0.02). In the untreated patients, antinuclear antibodies of IgG class were associated with BP [blood pressure] (P < 0.01) and fundus grading (P < 0.005). A family history of hypertension was found in 23.5% of the hypertensive males with AB and in 9.0% of the normotensive males (P < 0.10). These results are discussed in relation to reports of an association of AB with cardiovascular diseases. The presence of AB in essential hypertension is not necessarily due to drug induction.This publication has 15 references indexed in Scilit:
- Increased Serum Levels of Immunoglobulins in Untreated and Treated Essential HypertensionActa Medica Scandinavica, 1978
- IMMUNOLOGICAL ABNORMALITIES IN PATIENTS WHO HAD THE OCULOMUCOCUTANEOUS SYNDROME ASSOCIATED WITH PRACTOLOL THERAPYThe Lancet, 1976
- HL-A ANTIGENS IN ESSENTIAL HYPERTENSIONThe Lancet, 1975
- HL-A8 AND W15 IN DIABETES MELLITUS AND ESSENTIAL HYPERTENSIONThe Lancet, 1975
- Cutaneous and Ocular Reactions to PractololBMJ, 1974
- HYDRALAZINE‐INDUCED LUPOID SYNDROMEActa Medica Scandinavica, 1974
- ASSOCIATION OF AUTOANTIBODIES WITH SMOKING, CARDIOVASCULAR MORBIDITY, AND DEATH IN THE BUSSELTON POPULATIONThe Lancet, 1973
- Immune Responses to Hydralazine and Nuclear Antigens in Hydralazine-Induced Lupus ErythematosusAnnals of Internal Medicine, 1972
- Defined Immunofluorescence Studies of Cytoplasmic AntibodiesInternational Archives of Allergy and Immunology, 1972
- AUTOANTIBODIES RELATED TO TREATMENT WITH CHLORTHALIDONE AND α‐METHYLDOPAActa Medica Scandinavica, 1970