Effect of Fatigue on Susceptibility of Mice to Poliomyelitis

Abstract

Mice were forced to run in a revolving drum during the day preceding and for 8 hrs. each day subsequent to the intracerebral injection of the Lansing strain of virus. Control animals inoculated at the same time with the same amt. of virus were allowed to rest in their cages. In all 7 expts., the incidence of the disease as measured both by paralysis and by death was greater in the exercised animals than in the resting controls.