Effect of Aflatoxin on Human Leukocytes
- 1 February 1968
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 127 (2), 559-562
- https://doi.org/10.3181/00379727-127-32740
Abstract
Aflatoxin inhibits mitosis and causes breakage and trans-locations in the chromosomes of cultured human leukocytes. The nonrandom pattern of breakage was confined mainly to the largest chromosomes of the human complement. Chromosome no''s. 1 and 2 were particularly affected, while groups E, F, and G exhibited a lower than expected frequency of breaks. The effect of aflatoxin on human leukocytes is of the delayed type which is characteristic of chromosome breaking compounds such as alkylating agents.This publication has 5 references indexed in Scilit:
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