Antihistamines: Their Use and Abuse

Abstract

ANTIHISTAMINES no longer make the headlines. Now and then comments about them appear on the editorial page. More recently they have been found among the advertisements. Time is necessary for the clinical evaluation of any therapeutic agent. It is now five years since the first of these drugs became available to the practicing physician. In that period hundreds of articles, many reviews¹ and several books^{2 3 4} have appeared discussing the chemistry, pharmacology and physiology of the antihistamines and recounting clinical observations on their effect in numerous diseases and conditions.As with the advent of many new types of drugs, the appearance . . .