α-Melanocyte stimulating hormone promotes neurite outgrowth in chromaffin cells
- 4 January 1988
- journal article
- Published by Wiley in FEBS Letters
- Vol. 226 (2), 337-342
- https://doi.org/10.1016/0014-5793(88)81450-9
Abstract
Chromaffin cells from adult bovine adrenal medulla were found to develop neurites when cocultured with pituitary intermediate lobe (IL) cells. In coculture 51.7% of the chromaffin cells extended neurites compared with 12% in control cultures (chromaffin cells alone). A soluble factor released by IL cells was apparently involved as medium conditioned by contact with IL cells also promoted neurite outgrowth. Moreover, the addition of αMSH, one of the pro-opiomelanocortin-derived peptides secreted by IL cells, alone reproduced this effect in a dose-dependent manner. The data provide evidence for a neurotrophic role of αMSHKeywords
This publication has 27 references indexed in Scilit:
- Presence of immunoreactive α-melanotropin and β-endorphin in spinal motoneurones of the dystrophic mouseNeuroscience Letters, 1985
- The enhanced recovery of sensorimotor function in rats is related to the melanotropic moiety of ACTH/MSH neuropeptidesEuropean Journal of Pharmacology, 1983
- Phenotypic plasticity of cultured bovine chromaffin cells. I. Morphological changes induced by non-chromaffin cells and organ extracts, but not by mouse and bovine nerve growth factorDevelopmental Brain Research, 1983
- Nerve growth factor-mediated induction of tyrosine hydroxylase and of neurite outgrowth in cultures of bovine adrenal chromaffin cells: Dependence on developmental stageDevelopmental Biology, 1982
- Neuropeptides derived from pro-opiocortin: behavioral, physiological, and neurochemical effects.Physiological Reviews, 1982
- Morphological characteristics and stimulus-secretion coupling in bovine adrenal chromaffin cell culturesNeuroscience, 1980
- Establishment, characterization and fibre outgrowth of isolated bovine adrenal medullary cells in long-term culturesNeuroscience, 1980
- Structure and Biosynthesis of Pro-Adrenocorticotropin/Endorphin and Related Peptides*Endocrine Reviews, 1980
- Distribution of α-melanocyte-stimulating hormone in the rat brain: Evidence that α-MSH-containing cells in the arcuate region send projections to extrahypothalamic areasBrain Research, 1979
- Identification, characterization and stereotaxic mapping of intraneuronal α-melanocyte stimulating hormone-like immunoreactive peptides in discrete regions of the rat brainBrain Research, 1979