The diffusion of nandrolone through occluded and non-occluded human skin

Abstract

Diffusion constants have been measured for nandrolone in human cadaver skin in vitro under conditions which approximate to both the occluded and non-occluded topical therapeutic situation. The results suggest that occlusion affects the diffusion parameters only marginally, if at all, but appears to reduce the ability of the stratum corneum to ‘irreversibly’ bind a fraction of the applied dose. Studies of nandrolone diffusion in freshly excised human epidermis yield similar results to those from measurements on cadaver skin, and it has also been found that epidermal samples excised from non-involved sites of human psoriatic patients behave under these conditions in essentially the same way as normal epidermis.