ATP and the Conversion of Mevalonic Acid to Cholesterol and Precursors By Liver Homogenates.
- 1 December 1959
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 102 (3), 540-542
- https://doi.org/10.3181/00379727-102-25311
Abstract
The influence of adenosinetri-phosphate (ATP) on biosynthesis of cholesterol and precursors from mevalonic acid was studied with relatively crude (200 xg supernatant) and more refined (9000 xg supernatant) fractions of rat liver homogenate under aerobic and anaerobic conditions following preincubation with or without added ribonuclease. Mevalonic acid incorporation occurred under conditions favorable for oxidative phosphorylation or under conditions where the ATPase of tissue fragments had been removed by centrifugation (9000 xg). Ribonuclease inhibition of mevalonic acid utilization occurred only under O2 and in the presence of tissue fragments relatively rich in ATPase.Keywords
This publication has 4 references indexed in Scilit:
- Relationship Between Mevalonic Acid Utilization and ATP Content in Liver Homogenates Pretreated with Ribonuclease.Experimental Biology and Medicine, 1959
- Additional Evidence for the Existence of a New Factor Essential for Mevalonic Acid Utilization.Experimental Biology and Medicine, 1958
- Ribonuclease Inhibition of Mevalonic Acid Utilization.Experimental Biology and Medicine, 1958
- Factors Influencing Incorporation of Mevalonic Acid into Cholesterol by Rat Liver Homogenates.Experimental Biology and Medicine, 1957