Glucose intolerance in familial combined hyperlipidaemia
- 1 January 1998
- journal article
- research article
- Published by Wiley in European Journal of Clinical Investigation
- Vol. 28 (1), 24-32
- https://doi.org/10.1046/j.1365-2362.1998.00243.x
Abstract
Familial combined hyperlipidaemia (FCHL) is a common hereditary disorder. Hypertriglyceridaemia is associated with glucose intolerance and insulin resistance. To study glucose tolerance in FCHL patients with different lipid phenotypes [hypercholesterolaemia (IIA), mixed hyperlipidaemia (IIB), hypertriglyceridaemia (IV)], we investigated 253 family members and 92 spouses arising from 33 well-defined Finnish FCHL pedigrees. In oral glucose tolerance tests. the affected family members had higher values for glucose area under the curve than did non-affected family members (673 ± 127 min mmol L−1, 754 ± 145 min mmol L−1, 846 ± 180 min mmol L−1 and 838 ± 183 min mmol L−1 for phenotypes normal, IIA, IIB and IV respectively; P < 0.001 after adjustment for body mass index, waist circumference and age). Impaired glucose tolerance and diabetes were more common among affected than non-affected family members (prevalences of normal glucose tolerance 94.0%, 80.0%, 54.3% and 58.5% for phenotypes normal, IIA, IIB and IV). Affected FCHL family members were more glucose intolerant than non-affected family members. In men, this disturbance was not related to lipid phenotype nor was it explained by obesity.Keywords
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