Energetic coupling between DNA bending and base pair opening.
- 1 October 1988
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 85 (19), 7231-7235
- https://doi.org/10.1073/pnas.85.19.7231
Abstract
The pathway for base pair opening within a B-DNA duplex is investigated by theoretical molecular modeling. The results show that the disruption of a single base pair is energetically compatible with the deductions made from hydrogen exchange measurements. In addition, it is found that the opening process is greatly facilitated by DNA bending and that, conversely, once a base pair is disrupted, DNA can bend very easily. It appears that the energetic coupling between these two processes may play an important role in many biological reactions involving nucleic acid distortion.This publication has 18 references indexed in Scilit:
- Sequence Selectivity, a Test of the Nature of the Covalent Adduct Formed Between Benzo[a]pyrene and DNAJournal of Biomolecular Structure and Dynamics, 1987
- A General Approach to the Optimization of the Conformation of Ring Molecules with an Application to ValinomycinJournal of Biomolecular Structure and Dynamics, 1986
- Poly(dA-dT).cntdot.poly(dA-dT) two-pathway proton exchange mechanism. Effect of general and specific base catalysis on deuteration ratesBiochemistry, 1986
- Binding of Non-Intercalating Antibiotics to B-DNA: A Theoretical Study Taking Into Account Nucleic Acid FlexibilityJournal of Biomolecular Structure and Dynamics, 1986
- The Flexibility of the Nucleic Acids: (II) The Calculation of Internal Energy and Applications to Mononucleotide Repeat DNAJournal of Biomolecular Structure and Dynamics, 1986
- Determination of the kinetics of deuteration of DNA.cntdot.RNA hybrids by ultraviolet spectroscopyBiochemistry, 1985
- Molecular mechanical studies of base‐pair opening in d(CGCGC):d(GCGCG), dG5·dC5, d(TATAT):d(ATATA), and dA5·dT5 in the B and Z forms of DNABiopolymers, 1984
- Bent helical structure in kinetoplast DNAProceedings of the National Academy of Sciences, 1982
- Molecular mechanical studies of DNA flexibility: Coupled backbone torsion angles and base-pair openingsProceedings of the National Academy of Sciences, 1982
- Base-pair opening and closing reactions in the double helixJournal of Molecular Biology, 1979