Enantioselective radical cyclization controlled by a chiral aluminium reagent

Abstract

Free radical cyclization of cyclohexyl 8-iodo-nona-2,8-dienoate in the presence of a chiral aluminium reagent, prepared from (R)-3,3′-bis(triphenylsilyl)-1,1′-bi-2-naphthol and Me₃Al, gives optically active 2-(2-methylenecyclopentyl)acetate in 63% yield and 46% ee.