The activity of amantadine HCl, trihexyphenidyl HCl, ethopropazine HCl, atropine sulphate, mecamylamine HCl and L-dopa against effects provoked by nicotine injected intracerebrally(tremors, convulsions, loss of righting reflex) was studied. The antagonistic drugs were injected intraperitoneally or intracerebrally.The above mentioned drugs except L-dopa and atropine preventednicotine manifestations when given intraperitoneally. Amantadine, atropine and mecamylamine, resulted active when given intracerebrally (trihexyphenidyl, ethopropazine and L-dopa could not betested i.e.). Effects provoked by oxotremorine were counteracteby atropine, trihexyphenidyl, ethopropazine but not by amantadineand mecamylamine. Trihexyphenidyl, ethopropazine and atropine had anticarbamylcholine activity and mydriatic activity. Amantadine and mecamylamine were inactive or almost inactive.