METABOLISM OF METHOXYPHENAMINE IN MAN AND IN MONKEY

Abstract

Metabolites of methoxyphenamine in the urine of human subjects and monkeys [Macaca mulatta] were separated by GLC and identified by comparison of their chromatographic and mass spectrometric behavior with those of synthetic compounds. Aromatic O-demethylation, aromatic ring hydroxylation (both followed by glucuronide conjugation), and N-demethylation were shown to occur in man as well as in monkey. In man these were the principal metabolites, whereas in the monkey 3 additional unidentified major metabolites were formed.