Changes in the blood level and affinity to concanavalin A of rat plasma glycoproteins during acute inflammation and hepatoma growth

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Abstract
Plasma concentrations of 10 individual proteins were measured by electroimmunoassay in young male Buffalo rats following injection of turpentine oil or implantation of Morris hepatoma 7777. The highest relative responses to inflammation and tumor growth were found for .alpha.2-macroglobulin, .alpha.1-acute-phase globulin and .alpha.1-acid glycoprotein. As shown by crossed immuno-affinoelectrophoresis, the concanavalin A-reactive fractions of the latter 2 glycoproteins were predominantly increased in plasma from injured and tumor-bearing rats.