MECHANISM OF INHIBITION OF PROSTAGLANDIN BIOSYNTHESIS BY HYDROCORTISONE IN RAT LEUCOCYTES
Open Access
- 1 June 1979
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 66 (2), 161-163
- https://doi.org/10.1111/j.1476-5381.1979.tb13659.x
Abstract
Hydrocortisone (10 μg/ml) greatly inhibits the prostaglandin release by rat peritoneal leucocytes phagocytosing killed bacteria. The inhibition, which occurs after an initial latency of 30 min, is completely reversed by either actinomycin D (0.5 μg/ml) or cycloheximide (1 μg/ml). Since these antibiotics are known inhibitors of DNA-dependent RNA synthesis and protein synthesis respectively, it appears that the mechanism of inhibition of prostaglandin biosynthesis by hydrocortisone in rat leucocytes involves stimulation of transcription and induction of protein synthesis.Keywords
This publication has 20 references indexed in Scilit:
- Inhibition of prostaglandin biosynthesis by corticosteroids requires RNA and protein synthesisNature, 1978
- Stimulation of prostaglandin E production in cultured human fibroblasts by poly(I) · poly(C) and human interferonNature, 1977
- Mechanism of steroid action in inflammation: Inhibition of prostaglandin synthesis and releaseProstaglandins, 1976
- Steroid hormones, anti-inflammatory steroids and prostaglandinsPharmacological Research Communications, 1976
- The importance of phospholipase-A2 in prostaglandin biosynthesisBiochemical Pharmacology, 1976
- Hydrocortisone inhibits prostaglandin production by mouse fibrosarcoma cellsNature, 1975
- Corticosteroids inhibit prostaglandin production by rheumatoid synoviaNature, 1975
- Inhibition of release of prostaglandins as an explanation of some of the actions of anti-inflammatory corticosteroidsNature, 1975
- Mechanism of action of glucocorticoidsMetabolism, 1974
- Prostaglandins released by the SpleenNature, 1968