Effect of Hydroxyurea on the Frequency of Painful Crises in Sickle Cell Anemia
- 18 May 1995
- journal article
- clinical trial
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 332 (20), 1317-1322
- https://doi.org/10.1056/nejm199505183322001
Abstract
In a previous open-label study of hydroxyurea therapy, the synthesis of fetal hemoglobin increased in most patients with sickle cell anemia, with only mild myelotoxicity. By inhibiting sickling, increased levels of fetal hemoglobin might decrease the frequency of painful crises.Keywords
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