THE NATURE OF THE BLASTOGENIC MATERIAL IN THE MEDIUM FROM PERIPHERAL LEUKOCYTE CULTURES

Abstract

Some of the physical and chemical properties of blastogenic material contained in cell-free culture medium of 5-day mixed leukocyte cultures have been described. These properties seem similar in many respects to those of dog and mouse transplantation antigens which have been described by other workers. Characterization and purification of the blastogenesis factor may lead to increased understanding of transplantation immunity. In view of the relatively stable qualities of this factor, it may be possible to concentrate it in sufficient quantity to have practical application in tissue matching.