The practical importance of hypersensitiveness to wool fat (lanolin) and to wool makes it seem advisable to publish the report of the two following cases. In doing so we will be as brief as possible and will consider neither the theoretical points nor the literature concerning sensitizations to the so-called epidermals, confining ourselves to our observations and the practical aspects of the question. Recently Ramirez and Eller1called attention to a case of hypersensitiveness to wool fat that was in many ways similar to the cases we report here. For the sake of brevity we will give the essential points of the two cases together; both of these cases were mentioned by MacKee and one of us (M. B. S.) in the discussion of Sulzberger and Wise's2paper read at the Detroit session of the American Medical Association in 1930. REPORT OF CASES The patients observed were both