Factors controlling the effect of praziquantel on liver fibrosis inSchistosoma mansoni-infected patients
Open Access
- 1 February 2010
- journal article
- Published by Oxford University Press (OUP) in FEMS Immunology & Medical Microbiology
- Vol. 58 (1), 106-112
- https://doi.org/10.1111/j.1574-695x.2009.00640.x
Abstract
An association study of a cohort of 177 Sudanese patients infected with Schistosoma mansoni [82 (46%) males and 95 (54%) females] was conducted to evaluate the factors controlling the regression of liver fibrosis 39 months after treatment with praziquantel using ultrasound evaluation. Periportal fibrosis (PPF) was regressed in 63 (35.6%) patients, while the disease progressed to higher grades in 24 (13.6%) patients. The grade of PPF did not change in 90 (50.8%) patients. The mean values of portal vein diameter, splenic vein diameter and index liver size in subjects in whom PPF regressed after treatment were significantly lower than in subjects in whom the disease was progressed (PP=0.031 and P=0.003, respectively). The progression of hepatic fibrosis in males (15, 8.5%) was greater than that in females (9, 5.1%). Patients with regression or progression phenotypes tend to cluster in certain families. Our study indicated that regression, progression and stabilization of PPF after praziquantel therapy is controlled by gender, age, grade of fibrosis and possibly inherited factors.Keywords
This publication has 15 references indexed in Scilit:
- Cytokine Regulation of Periportal Fibrosis in Humans Infected with Schistosoma mansoni: IFN-γ Is Associated with Protection Against Fibrosis and TNF-α with Aggravation of DiseaseThe Journal of Immunology, 2002
- Contribution to the study of collagen degradationJornal Brasileiro de Patologia e Medicina Laboratorial, 2002
- Efficacy of praziquantel against Schistosoma mansoni with particular consideration for intensity of infectionTropical Medicine & International Health, 2000
- Severe Hepatic Fibrosis in Schistosoma mansoni Infection Is Controlled by a Major Locus That Is Closely Linked to the Interferon-γ Receptor GeneAmerican Journal of Human Genetics, 1999
- Infection and disease in human schistosomiasis mansoni are under distinct major gene controlMicrobes and Infection, 1999
- Full results of the genome-wide scan which localises a locus controlling the intensity of infection by Schistosoma mansoni on chromosome 5q31–q33European Journal of Human Genetics, 1999
- Developmental effects of endocrine-disrupting chemicals in wildlife and humans.Environmental Health Perspectives, 1993
- The use of diagnostic ultrasound in schistosomiasis — Attempts at standardization of methodologyActa Tropica, 1992
- In vitro and in vivo association of transforming growth factor-beta 1 with hepatic fibrosis.The Journal of cell biology, 1989
- Experimental Chemotherapy of Schistosomiasis mansoniAdvances in Parasitology, 1968