Abstract
“Catapres” is a potent drug with a unique mode of action. It is free from serious toxicity, and side effects are minor and rapidly reversible. Its major advantage is that it does not cause postural hypotension or other symptoms of sympathetic blockade. It is effective in hypertension of all grades of severity, and when not entirely effective alone, greatly potentiates the effect of guanethedine. “Catapres” is considered to be a suitable alternative to methyldopa as Initial therapy in hypertensive disease.