Screening for drug toxicity by wave lengths greater than 3,100 A
- 1 January 1967
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Dermatology
- Vol. 95 (1), 12-15
- https://doi.org/10.1001/archderm.95.1.12
Abstract
Normal healthy adult male volunteers receiving 150 mg demethylchlortetracycline 4 times daily were exposed to several forms of light including the fluorescent bulb, the Kromayer unit, the carbon arc lamp, and natural sunlight. All efforts to demonstrate phototoxicity of this standard agent failed until the erythema producing rays of natural sunlight were excluded with plastic film (Mylar). When the erythema producing rays of natural sunlight are removed with plastic and the subjects exposed for from two to four hours of natural sunlight, obvious phototoxicity occurred. DMCT treated subjects demonstrated frank erythema, where as control subjects had either pigment darkening (Meirowsky phenomena), or no response. Attempts to reproduce this result with artificial light sources failed. This model is proposed as a screening method to ascertain the phototaxicity of compounds absorbing light rays longer than 3100 Angstroms (A).This publication has 2 references indexed in Scilit:
- Photo-Irradiation Studies of Two TetracyclinesArchives of Dermatology, 1963
- Studies on Photosensitivity Due to Demethylchlortetracycline11From the Department of Dermatology of the New York University Post-Graduate Medical School and the Skin and Cancer Unit of the University Hospital, New York, N. Y.Journal of Investigative Dermatology, 1961