Primary pulmonary hypertension: effects of nifedipine.
Open Access
- 1 September 1980
- Vol. 44 (3), 352-356
- https://doi.org/10.1136/hrt.44.3.352
Abstract
The results of the medical treatment of primary pulmonary hypertension are usually very poor. A case of severe primary pulmonary hypertension in chronic heart failure was treated with the calcium antagonist nifedipine, a powerful vasodilator which acts directly on vascular smooth muscle. Nifedipine, administered in a dose of 20 mg sublingually, caused a pronounced fall in pulmonary and systemic vascular resistances (54 and 49%, respectively) and a rise in cardiac output (90.3%). Improvement was maintained over a three-month period. These data suggest that nifedipine can be used in the treatment of this condition.Keywords
This publication has 13 references indexed in Scilit:
- Isoproterenol as a potential pulmonary vasodilator in primary pulmonary hypertensionThe American Journal of Cardiology, 1978
- Diazoxide in treatment of primary pulmonary hypertension.Heart, 1978
- Specific Pharmacology of Calcium in Myocardium, Cardiac Pacemakers, and Vascular Smooth MuscleAnnual Review of Pharmacology and Toxicology, 1977
- Inhibition of hypoxic pulmonary vasoconstriction by calcium antagonists in isolated rat lungs.Circulation Research, 1976
- Primary Pulmonary HypertensionCirculation, 1970
- Primary Pulmonary Hypertension in a ChildCirculation, 1969
- Loss of reactivity of the pulmonary vascular bed in primary pulmonary hypertensionAmerican Heart Journal, 1963
- Primary pulmonary hypertensionThe American Journal of Cardiology, 1961
- Intracardiac infusion of acetylcholine in primary pulmonary hypertensionAmerican Heart Journal, 1960
- Effect of Acetylcholine on Pulmonary Vascular Resistance in a Patient with Idiopathic Pulmonary HypertensionCirculation, 1959