A Simple One-Pot Synthesis of Functionalized Ketimines from Ketones and Amine Hydrochloride Salts

Abstract

Functionalized ketimines of the general formula RR′C(=NCH₂Y) [R and R′ = Ph, alkyl; Y = CN (1), CH₂Cl (2), COOMe (3)] have been prepared by the condensation of ketones with the corresponding primary amine hydrochloride salts [NH₂CH₂Cl.HCl (4), NH₂CH₂CH₂Cl.HCL (5) and NH₂CH₂COOMe HCl (6), respectively]. The reported reaction proceeds mildly in a single step without the need of a previous isolation of the free amine from its salt. N,N-Dimethylformamide (DMF) is used as the solvent and TiCl₄ as the drying agent.