IN VITRO STUDIES ON NORMAL, STIMULATED AND IMMUNOLOGICALLY ACTIVATED MOUSE MACROPHAGES

Abstract

The intracellular generation time of L. monocytogenes is increased in monolayers of PE [peritoneal exudate] macrophages from mice immunized with BCG, Listeria and TAB [typhoid-paratyphoid] vaccine as compared with monolayers of PE macrophages from normal mice stimulated i.p. with proteose-peptone. Nonspecifically stimulated and immunologically activated macrophages, although sharing several other characteristics, differ in their capacity to control intracellular bacterial infection.