Population genetics of the angiotensin‐converting enzyme in Chinese.
Open Access
- 1 February 1994
- journal article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 37 (2), 212-214
- https://doi.org/10.1111/j.1365-2125.1994.tb04264.x
Abstract
A genetic polymorphism exists for the angiotensin-converting enzyme (ACE) gene which accounts for 44% of the variance of circulating ACE activity in a normal Caucasian population. The presence or absence of a 250 bp fragment in intron 16 of the gene serves as a marker for this polymorphism. One hundred and eighty-nine normal Chinese subjects were genotyped and phenotyped for this ACE polymorphism. The frequencies of the deletion and insertion alleles among Chinese are 0.3 and 0.7 respectively, indicating a much higher prevalence of the insertion allele than had been reported among Caucasians.Keywords
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