Risk of Left Ventricular Dysfunction in Patients with Probable Alzheimer's Disease with APOE*4 Allele

Abstract

OBJECTIVE: To examine the association between the APOE genotype and cardiovascular disease in Alzheimer's disease (AD) patients.DESIGN: Case register study of 100 consecutive referrals to a Memory Clinic where type of dementia and cardiovascular comorbidity were diagnosed and APOE genotype was determined.SETTING: The Memory Clinic, University Hospital Rotterdam Dijkzigt.PARTICIPANTS: One hundred Memory Clinic patients, 59 to 91 years of age, who attended the Memory Clinic in the period between January 1994 and March 1996.MEASUREMENTS: Relative risk of cardiovascular morbidity in probable AD, based on clinical and ECG findings.RESULTS: The diagnosis of probable AD was more frequent in APOE*4 allele-carrying AD patients. When comparing homozygotes for APOE*4 with homozygotes for APOE*3, a nine-fold increase in prevalence of cardiac ischemia on ECG was found in the former. When grouping parameters of left ventricular dysfunction, the prevalence was 7.2 (95% confidence interval 1.2–42.6) times greater in probable Alzheimer patients with APOE4/4.CONCLUSIONS: In patients with probable AD, APOE*4 is associated with cardiac disease indicative of left ventricular dysfunction. J Am Geriatr Soc 46:962–967, 1998.