Influence of the H2-receptor blocking agent metiamide on the clonidine-induced changes in the brain catecholamine turnover
- 1 September 1980
- journal article
- research article
- Published by Springer Nature in Journal of Neural Transmission
- Vol. 47 (3), 175-180
- https://doi.org/10.1007/bf01250599
Abstract
Metiamide (800μg intracerebroventricularly to rats) enhanced the DOPA accumulation in noradrenaline-predominant brain areas following DOPA decarboxylase inhibition and it accelerated theα-methyltyrosine-induced disappearance of noradrenaline in the brain, both normally and after clonidine (0.1 mg/kg i.p.). These findings indicate that metiamide stimulates the release of noradrenaline. They can explain why metiamide antagonizes the clonidine-induced hypotension.This publication has 19 references indexed in Scilit:
- An interaction of histamine H2-receptor antagonists with the noradrenergic system in rat brainEuropean Journal of Pharmacology, 1978
- Clonidine-induced hypotension: Further evidence for a central interaction with histamine H2 receptor antagonists in the rat☆Neuropharmacology, 1978
- Further evidence for central histamine H2-receptor involvement in the hypotensive effect of clonidine in the ratEuropean Journal of Pharmacology, 1977
- Possible involvement of central histamine H2-receptors in the hypotensive effect of clonidineNature, 1976
- Noradrenaline synthesis and utilization: Control by nerve impulse flow under normal conditions and after treatment with alpha-adrenoreceptor blocking agentsNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1976
- Different alpha-adrenoreceptors in the central nervous system mediating biochemical and functional effects of clonidine and receptor blocking agentsNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1976
- The determination of dopamine by a modification of the dihydroxyindole fluorimetric assayBritish Journal of Pharmacology, 1973
- Action of -adrenergic blocking drugs on the sympathetic centres and their interactions with the central sympatho-inhibitory effect of clonidine.1973
- Evidence for a central noradrenaline receptor stimulation by clonidineLife Sciences, 1970
- Refillment of the catecholamine stores with 3,4-dihydroxyphenylalanine after depletion induced by inhibition of tyrosine-hydroxylaseLife Sciences, 1966