Applications of heteroduplex analysis for mutation detection in disease genes
- 1 January 1995
- journal article
- review article
- Published by Hindawi Limited in Human Mutation
- Vol. 6 (4), 281-287
- https://doi.org/10.1002/humu.1380060402
Abstract
Double‐stranded heteroduplex molecules that form between a mutant and wild‐type DNA strand are often distinguished from homoduplex molecules upon gel electrophoresis. This method, heteroduplex analysis (HA), can be performed rapidly without radioisotopes or specialized equipment. Modifications and enhancements of the HA method have been developed that increase the sensitivity of detection of single‐base pair alterations. © 1995 Wiley‐Liss, Inc.†Keywords
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