Vasoactive Intestinal Peptide Stimulation of Pineal Serotonin‐N‐Acetyltransferase Activity: General Characteristics
- 1 January 1983
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 41 (1), 146-153
- https://doi.org/10.1111/j.1471-4159.1983.tb11826.x
Abstract
Vasoactive intestinal polypeptide (VIP) stimulates basal serotonin-N-acetyltransferase (NAT) activity in pineals in organ culture and enhances the effects of catecholamines in inducing the enzyme. VIP appears to act postsynaptically; its action is independent of the beta receptor and is dependent upon protein synthesis. Its effects may be mediated by a receptor. The magnitude of the pineal response to VIP varies with age, is greater in pineals maintained in 48-h organ culture than in those in acute culture, and can be detected in pineals from newborns after 48-h organ culture. Intravenous administration of VIP can increase pineal NAT activity in vivo.Keywords
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