THE MECHANISM OF THE ANTAGONISM BY NALOXONE OF ACUTE ALCOHOL INTOXICATION
Open Access
- 1 November 1981
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 74 (3), 514-516
- https://doi.org/10.1111/j.1476-5381.1981.tb10458.x
Abstract
Naloxone lowers blood-ethanol concentration and causes a simultaneous reversal of the disturbances in the redox states of the hepatic nicotinamide-adenine dinucleotide (phosphate) couples in acutely-ethanol-intoxicated rats. It is suggested that these effects of naloxone form the basis of its antagonism of acute alcohol intoxication.Keywords
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